About Vitiligo

Vitiligo VrfVitiligo (pronounced vit-ill-EYE-go) is a skin disease that causes skin and overlying hair to gradually lose color. It is unpredictable and can affect any or all parts of the body.  

Contrary to popular belief, vitiligo is not a cosmetic disorder but a systemic disease affecting the largest body organ and other vital systems. Vitiligo is a life-long condition and patients are unlikely to ever be completely free of it. 

The good news is that vitiligo – upsetting as it can be to those living with it – is neither life threatening nor contagious. A proper treatment protocol can control the disease and make it less visible. 

What Are The Symptoms Of Vitiligo?

Vitiligo signs vary considerably from person to person, but are more pronounced in people with dark or tanned skin. Some people only get a few small, white patches (or lesions) that progress no further. Other people get bigger white patches that join up across large areas of their skin.

Vitiligo commonly affects skin areas that are exposed to sun, as well as previous sites of skin injury, and body folds - e.g. armpits. Areas around body openings – mouth, nose etc - and the genitals may also be affected. Initially, the vitiligo may start as a patch that is slightly paler than the rest of your skin, but will gradually become completely white. 

The edges of the patch may be smooth or irregular and may have an inflamed red border. Typically, vitiligo produces symmetrical depigmented areas of skin that otherwise appear perfectly normal. Hairs above vitiligo patches may also lose pigment and appear white. A halo nevi – a mole with a white ring or ‘halo’ around it, usually on the trunk – can be an early warning sign of vitiligo.

An early distinction between two basic types of vitiligo - segmental (or focal) and generalized - is very important in predicting disease activity and choosing the right treatment. Yet, not every white lesion is a sign of vitiligo. A well-trained dermatologist should be able to distinguish vitiligo from contact leukoderma, or more than twenty other conditions with similar symptoms.

How Many People Have Vitiligo?

The average prevalence of vitiligo is between 0.5% to 2% of the global population, but local numbers may vary from 0.004% to 9.98%, depending on the region and age group. The total number of people suffering from vitiligo is estimated at around 65-95 million people worldwide. However, the actual number may be much higher because vitiligo is an underreported disease.

What Is Known About Vitiligo?

Surprisingly, the causes of vitiligo are yet to be precisely established - despite decades of intense research. 

What we do know is that a complex and poorly understood chain of reactions is controlled by many genes involved in the immune system response and melanogenesis. 

We don’t yet understand how combinations of seemingly hundreds of genes result in a vitiligo patch. But we’ve discovered that an obscure triggering event creates stress in the pigment-producing cells of the skin. An over-reactive immune system then mistakenly identifies these stressed-out cells as intruders. Specialized cells called T-cells neutralize these ‘enemies,’ driving progressive skin depigmentation. This can happen to anyone, at any age, in any social group.

The current thinking is that vitiligo represents a group of immune-mediated disorders with a similar outcome – the appearance of white patches on the skin. This convergence theory states that intense psychological stress, genetic predisposition, altered cellular environment, exposure to toxins and impaired digestion can all contribute to the initiation process of vitiligo. 

Autoimmune mechanisms are likely to underlie generalized vitiligo, while a more localized phenomenon may be responsible for the segmental type. Vitiligo may also develop at the site of physical skin trauma – this is known as the 'Koebner phenomenon.'

Nearly half of vitiligo patients report the disease appearing as a tiny blotch that later spread to a wide pattern after severe physical or mental stress. These are called precipitating factors, because they are not the cause of the disease, but induce its appearance and/or progression. For instance, liver and thyroid diseases could be precipitating factors for vitiligo.

About half of vitiligo cases begin in childhood, often popping up in springtime without warning. Children with vitiligo may have a higher chance of developing other autoimmune diseases, such as alopecia areata, diabetes mellitus, pernicious anemia, Addison's disease and – although rare – hypothyroidism, which is particularly worrying in the young because of its potential impact on growth and health status.

Children born to parents who both have the disorder are more likely to develop vitiligo. However, most children will not get vitiligo - even if one parent has it. In children with segmental vitiligo, there is often no family history of vitiligo or other autoimmune disorders.

Generalized vitiligo is associated with a tendency to autoimmune illnesses, the most common being thyroid disease. Weak correlations between vitiligo and endocrinopathies, type 1 diabetes, Addison’s disease, lupus, rheumatoid arthritis, and alopecia areata are also observed. Some small studies have suggested vitiligo might negatively affect hearing and eyesight. 

On the positive side, vitiligo has a protective benefit against melanoma and other deadly skin cancers. And because of the hyper-active immune system, those with vitiligo often say they are less affected by common colds.

The course of vitiligo is usually progressive, with phases of long-term stability, or even spontaneous reversal. The average remission period after successful treatment of active vitiligo is four years.

What May Cause Vitiligo?

We know the cause is pre-wired in your genes, just waiting for a bad luck moment. In about half of all cases this can be a specific trigger, or an unfortunate combination of benign conditions. In the other half, the cause of vitiligo remains unknown.

Psychological stress is the most frequently reported trigger for vitiligo. Severe sunburn, physical skin damage, prolonged contact with certain chemicals may induce or worsen vitiligo. Hormonal changes during pregnancy, delivery and menopause may be the culprit. Parasites and chronic gastritis that impair absorption of vital elements by the digestive system may also indirectly cause vitiligo. 

Chemical triggers include materials with: 

  • p-phenylenediamine (also known as para-phenylene diamine or PPD), 
  • para-tertiary butylphenol (PTBP), and
  • monobenzylether of hydroquinone (MBH).

These are commonly found in hair dyes, perfume, cosmetics, detergents, cleansers, insecticides, rubber condoms, rubber slippers, black socks and shoes, print inks, motor oil additives and germicidal soaps. 

How Is Vitiligo Treated?

Simply put, patients can do one of three things with vitiligo: 

  • Try to restore pigmentation, 
  • Camouflage the white patches, or 
  • Destroy the remaining color to have all-white skin. 

Vitiligo should ideally be treated within two or three months of its first appearance, because as the condition progresses it becomes harder – although by no means impossible – to treat. Even ten, twenty or thirty-year old vitiligo spots may be re-pigmented with enough patience.

However, there is currently neither a cure for vitiligo, nor a universally accepted method for limiting the spread of the disease. Although many treatments are used to manage vitiligo, none is licensed specifically in the EU or the US - for this purpose. Also, it is not possible to predict what will work best for which patients.

Factors to consider include age of patient and disease onset, type of vitiligo and localization, familial and disease history, overall health condition and comorbidities, living and working environments, prospects of frequent travel or military service, financial situation, access to certain treatments, and most importantly - personal motivation. About a third of patients are non-respondents to any therapy. 

Symptoms are temporarily reversible with a range of treatments, and their combination works far better than a monotherapy. Light therapy remains a gold standard but it may take one or two years to restore natural skin color. Dietary supplements or vitamins can only mildly enhance phototherapy effectiveness and are incapable of creating a lasting effect on their own. Experimental treatments for vitiligo like afamelanotide, HSP70i, JAK inhibitor, prostaglandin, or simvastatin might work for some people, but researchers just haven’t figured out exactly who that is yet.

White lesions frequently reappear when treatment is discontinued, with relapse occurring in nearly half of all patients within four years of stopping treatment. This relapse can be significantly decreased using periodic treatment with supportive procedures. 

WARNING! Please do not self-diagnose, self-prescribe or self-treat based on ideas contained on this website, or any other publication. Recommendations provided here are for your general knowledge and discussion with a specialist only. These must be tailored by a doctor to an individual patient. It is important to consult with an experienced specialist – via telemedicine or in-person – before starting any treatment for yourself or your child.

Read more about most common Vitiligo Treatments

Vitiligo Treatment Costs

  • Doctor visit. For US-based patients without health insurance, an office visit typically costs $50-$200. With insurance, copay is $5 -$30 or coinsurance of 10%-50%, or more.
  • Topical treatments. A potent topical corticosteroid, such as clobetasol propionate, costs $20 - $300 or more, depending on whether it's a brand or its generic equivalent. Immunomodulator like Tacrolimus costs $200 or more.
  • Phototherapy. Conventional phototherapy cost is $85-$100 per treatment, and patients often require 180-220 sessions. Laser treatment starts at $150 or more per session (depending on the size of depigmented area), patients often require 20-30 sessions. Medicare reimburses $76 per non-targeted UVB treatment, and $150-$240 per targeted UVB treatment but not for laser treatments. Home phototherapy device costs in the range of $250-$4,000 and can be covered by insurance. 
  • Camouflage such as self-tanners or concealing cosmetics to hide white lesions costs $25-$35 per container.

Mega-stores like Walmart or Costco often sell prescription and over-the-counter drugs at significant savings, while many hospitals offer discounts of 30% or more to cash-paying patients.

Questions and Answers

We provide a free brochure containing general information about vitiligo and answers to the most frequently asked questions. Individual sections describe what vitiligo is, who is affected, symptoms, how it is diagnosed, and treatment options. If you have further questions, you may wish to discuss them with your dermatologist or physician.

Read it online or download in one of seven languages here

A Brief History of Vitiligo

The History of Vitiligo can be traced to as early as Rig Veda, an ancient Indian sacred collection of Vedic Sanskrit hymns. The term vitiligo was perhaps derived from the Latin word 'vitelius' - used to describe the white flesh of calves. The first written use of the word to Celsus in his classic Latin book De Medicina in the first Century AD. 


Whichever path you took through this website, by reading it you'll have a better overview of vitiligo than 99% of people who live with it, or are helping a family member who has vitiligo. 

If you are interested in taking part in clinical trials of new therapies, start with the online service of the U.S. National Institutes of Health at www.ClinicalTrials.gov

Lastly, we strongly recommend reading 'A No-Nonsense Guide To Vitiligo.' In this book, Yan Valle – author, campaigner and CEO of Vitiligo Research Foundation – cuts through the myths and misinformation that surround vitiligo to tell you what you really need to know.

Vitiligo Tips CoverBuy this book and you will:

  • Save the countless hours spent searching the web for information, only to realize most of it’s worthless.
  • Save all the time and effort spent on seeing non-specialist doctors who can’t help you.
  • Save the thousands of dollar spent on bogus supplements, snake oil cures and confusing research papers.

A thoroughly researched, easy-to-read and jargon-free guide to vitiligo – this is essential reading for vitiligo patients, or anyone interested in the condition. Available in both print and ebook formats through our online store.

Disclaimer of Endorsement and Liability

The Vitiligo Research Foundation (VRF) does not endorse or recommend any commercial products, processes, or services.

Please be advised that all information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. You should seek prompt medical care for any specific health issues and consult your physician or health practitioner. Users are warned against changing any aspects of their treatment, diet or lifestyle based on this information without first consulting a registered medical practitioner. While every precaution is taken to ensure accuracy, VRF makes no warranty as to the reliability, accuracy, timeliness, usefulness or completeness of the content which reflect personal opinion of the authors.

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