Genetic study in vitiligo
Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility.
Minashkin MM, Salnikova LE, Lomonosov KM, Korobko IV, Tatarenko AO.
Center for Innovative Biotechnologies "Allele", Moscow, Russia.
Vitiligo is an acquired pigmentary disorder with several proposed pathogenesis mechanisms and complex multifactorial genetic predisposition. We analyzed 65 polymorphisms in genes potentially relevant to vitiligo pathogenesis mechanism to reveal novel and confirm reported genetic risk factors in general Russian population. We found that polymorphism rs1138272 (TC + CC) in GSTP1 gene encoding enzyme involved in xenobiotic metabolism is associated with vitiligo (Bonferroni adjusted P value 0.0015) with extraordinary high odds ratio 13.03, and haplotype analysis confirmed association of GSTP1 gene with vitiligo risk. Moreover, analysis of variations in several genes encoding enzymes of xenobiotic metabolism showed that higher risk of vitiligo is associated with higher number of risk alleles. This finding reveals possible contribution of genetic background to observed imbalance of oxidative stress control in vitiligo through cumulative effect of multiple genetic variations in xenobiotic metabolizing genes, supporting the concept of multigenic nature of vitiligo with multiple low-risk alleles cumulatively contributing to vitiligo risk.
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What is coming?
New York Vitiligo Community Meeting
Our next meeting will be after the World Vitiligo Day conference in Detroit on Thursday, July 20th, 2017, at 7PM - 8:30PM on the 11th floor of NYU's Ambulatory Care Ce...20 July 2017 19:00, 240 East 38th Street, New York, NY
Master Class On Vitiligo In Pediatric Age
will be held alongside “International Forum on Paediatric Dermatology”, which will take place in Rome (Italy), on October 5-7, 2017. This is an exciting opportunity t...06 October 2017 09:00, P.zza Giovanni Randaccio, 1 - Rome...
Polypodium leucotomos as an adjunct treatment for vitiligo?
Extracts of the tropical fern Polypodium leucotomos appear to possess beneficial properties for the vitiligious skin. Polypodium leucotomos (also classified as Polypo...
Will it spread?
The condition varies from person to person. Some people only get a few small, white patches that progress no further. Other people get bigger white patches that join u...
How can I cure vitiligo?
There is no cure for vitiligo, but there are a number of effective treatment options that can be discussed with your GP or dermatologist. The aim of treatment is to st...
I have vitiligo: will my children have vitiligo, too?
In some cases vitiligo seems to be inherited and run in families, with children whose parents have vitiligo being at increased risk of developing the condition themsel...