Systemic Analyses of Immunophenotypes
Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo: implication of defective natural killer T cells.
Zhou L, Li K, Shi YL, Hamzavi I, Gao TW, Henderson M, Huggins RH, Agbai O, Mahmoud B, Mi X, Lim HW, Mi QS.
Henry Ford Immunology Program, Henry Ford Hospital, Detroit, MI, USA. email@example.com
Although it is widely believed that non-segmental vitiligo (NSV) results from the autoimmune destruction of melanocytes, a clear understanding of defects in immune tolerance, which mediate this uncontrolled self-reactivity, is still lacking. In the present study, we systemically evaluated circulating regulatory T (Treg) cells, including CD4(+) CD25(+) FoxP3(+) Treg cells and invariant natural killer T (iNKT) cells, as well as naïve and memory CD4(+) and CD8(+) T cells and their cytokine production, in a cohort of 43 progressive NSV patients with race-, gender-, and age-matched healthy controls. We found that the general immunophenotypes of CD4(+) and CD8(+) T cells and the percentage of CD4(+) CD25(+) FoxP3(+) Tregs were comparable between NSV and healthy controls. However, percentages of peripheral iNKT cells were significantly decreased in NSV patients compared to that in healthy controls. Our data confirm the previous notion that the percentage of peripheral CD4(+) CD25(+) FoxP3(+) Tregs remains unaltered in NSV and suggests the involvement of defective iNKT cells in the pathogenesis of NSV.
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What is coming?
XXIII Master Class in Cuba
will be held as a part of INDERCOS Winter Meeting, in collaboration with Cuban Vitiligo Support and Research Group. International and national expert speakers will di...16 November 2017 09:00, Hotel Nacional de Cuba, Habana, Cuba
High-level Meeting on the Asian and Pacific Decade of People With Disabilities
The UN's Economic and Social Commission for Asia and the Pacific (ESCAP), in cooperation with the China Disabled Persons’ Federation (CDPF), is organizing the High-lev...27 November 2017 09:00, Beijing, China
Can Ginkgo Biloba help with vitiligo?
Ginkgo Biloba extract seems to be a simple, safe and fairly effective therapy for arresting the progression of the vitiligo. Ginkgo Biloba is known to have anti-inflam...
What tests should be done?
No tests are usually necessary to make the diagnosis. The white patches may be seen more easily under Wood's light examination.
How to get insurance coverage for vitiligo treatments?
Most of health insurance companies will initially reject claims for vitiligo doctor visits or phototherapy treatments but with enough efforts you can have a substantia...
Is it possible to stop the progression of vitiligo?
It is true that vitiligo progression could be stopped in 4 out of 5 cases by the use of potent systemic corticosteroids. However, systemic corticosteroids might ha...