What causes vitiligo?
The precise cause of vitiligo is not well understood. The white areas appear due to loss of the pigment (melanin) that gives skin its color and protects it from the sun’s ultraviolet rays. Factors such as stress, physical illness, skin damage, certain chemicals and drugs, pregnancy and severe sunburn may trigger or worsen vitiligo.
It remains unclear what causes damage to melanocytes and their subsequent total inactivation and/or disappearance in vitiligo skin. There are several theories; the most prominent are autoimmune, neurohumoral, related to abnormal detachment of melanocytes from the epidermal layers and autocytotoxic. None are mutually exclusive, and it is likely that each of them partially contribute to the disease development.
The current thought is that vitiligo represents a group of different disorders with a similar outcome: the appearance of white patches on the skin.
The convergence theory states that stress, accumulation of toxic compounds, infections, autoimmunity, genetic predisposition, altered cellular environment, and impaired melanocyte migration can all contribute to the vitiligo initiation process. Autoimmune mechanisms are likely to underlie generalized vitiligo, while a more localized phenomenon (i.e. the altered activities of sensitive nerves in the skin) may be responsible for segmental or focal vitiligo. A site of a skin physical trauma may develop vitiligo; it is called a “Koebner phenomenon.”
Abstract from Vitiligo Q&A »»»
Disclaimer of Endorsement and Liability
The Vitiligo Research Foundation (VRF) does not endorse or recommend any commercial products, processes, or services.
Please be advised that all information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. You should seek prompt medical care for any specific health issues and consult your physician or health practitioner. Users are warned against changing any aspects of their treatment, diet or lifestyle based on this information without first consulting a registered medical practitioner. While every precaution is taken to ensure accuracy, VRF makes no warranty as to the reliability, accuracy, timeliness, usefulness or completeness of the content which reflect personal opinion of the authors.
I support the petition to designate June 25 as Vitiligo World Day and save millions of people worldwide from social isolation and persecution.
What is coming?
11th session of the Conference of States Parties to the CRPD
The 11th session Convention on the Rights of Persons with Disabilities (CRPD) will take place at the United Nations Headquarters, New York, from 12 to 14 June 2018. Mo...12 June 2018 09:00, UN Plaza, New York
Master Class On Vitiligo In Pediatric Age
will be held alongside “International Forum on Paediatric Dermatology”, which will take place in Rome (Italy), on October 5-7, 2017. This is an exciting opportunity...06 October 2018 09:00, P.zza Giovanni Randaccio, 1 - Rome...
Can Scenesse be used for vitiligo treatment?
The drug Scenesse from Clinuvel has been tested in clinical trials in relation vitiligo. Profs. Henry Lim, Mark Lebwohl and coauthors reported (PubMed) results of mult...
What causes vitiligo?
The precise cause of vitiligo is not well understood. The white areas appear due to loss of the pigment (melanin) that gives skin its color and protects it from the su...
Polypodium leucotomos as an adjunct treatment for vitiligo?
Extracts of the tropical fern Polypodium leucotomos appear to possess beneficial properties for the vitiligious skin. Polypodium leucotomos (also classified as Polypo...