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The Quiet Case For Older Vitiligo Therapies
Research Update
The Billion-Dollar Molecule Problem
And maybe a healthy one.
Our paper, “Making the Case for Azathioprine, Methotrexate, and Cyclosporine in Active Vitiligo Management”, has successfully passed peer review and has been accepted for publication in Frontiers in Medicine.
For the past few years, vitiligo conversations have largely revolved around shiny new molecules, JAK inhibitors, and the future of precision immunology.
Important progress, absolutely.
But much of the world still lives in a different reality.
Many patients remain in low-resource settings where newer therapies are unavailable, unaffordable, or simply nonexistent outside conference slides and press releases.
This paper revisits an uncomfortable but necessary question: what do we do for active vitiligo patients today — not in the imagined future, but in real clinics with real constraints? or for those unfit for TCIs or JAKs?
We examine the evidence, limitations, and practical role of older systemic immunomodulators like azathioprine, methotrexate, and cyclosporine — treatments that may not be fashionable, but remain relevant for many clinicians worldwide.
Not every important medical conversation needs to start with a billion-dollar molecule.
Continue reading: Making the Case for Azathioprine, Methotrexate, and Cyclosporine in Active Vitiligo Management
Sometimes it starts with asking whether we’ve quietly abandoned useful tools simply because they stopped being commercially interesting.
Yan Valle
Prof. h.c., CEO, Vitiligo Research Foundation
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