TrialHub

TrialHub

Clinical trials are experiments that test how well new drugs, treatments or devices work in people. Trials progress through Phases I-IV to test a drug candidate, find the appropriate dosage, and look for side effects. The goal is to determine whether a medicine is both safe and effective.

Each new phase of a clinical trial builds on information from previous stages; each designed to find out specific information. The findings from clinical trials are submitted to the U.S. Federal Drug Administration or it’s counterpart European Medicines Agency to review and determine if a new treatment will be approved to go to market.

Clinical trials listed here below aim to find better ways to diagnose, treat or prevent vitiligo. We provide you with information about a trial's purpose, recruitment status, age restrictions, locations, and contact numbers for more details.

Current Trials

06 Feb `23New Jersey, USA
A Clinical Research Study of VYN201 Ointment in Adults with Vitiligo

 

Official Title: A Phase 1, Single and Multiple Ascending Dose (SAD/MAD) Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of VYN201 in H...

01 Dec `22Multiple locations in USA, CANADA, JAPAN
A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents With Vitiligo

 

Official title: A phase 3 randomized, double-blind, 52-week placebo-controlled, multi-center study investigating the efficacy, safety, and tolerability of ritlecitinib in adult and adolescent pa...

20 Nov `22Cairo, EGYPT
Autologous Cellular Graft in Surgical Treatment of Vitilig

 

Official Title: Autologous Cellular Micro-graft in Surgical Treatment of Stable Resistant Vitiligo: A Randomized Self-controlled Trial

Brief Summary:&nb...

01 Nov `22Worcester, Massachusetts, USA
Evaluating the Efficacy and Safety of Metformin in Vitiligo

 

Official Title: Metformin as a Novel Treatment for Vitiligo by Targeting CD8+ T Cell Metabolism

Brief Summary: Metformin modulates metabolism in mu...

19 Oct `22Nice, Alpes-maritimes, FRANCE
Assessment of Circulating Fubctional Mitochondrias in Vitiligo Patients

 

Official Title: Assessment of Circulating Fubctional Mitochondrias in Vitiligo Patients as Compared to Controls

Experimental: Vitiligo Group.  The subjects will be selected from amo...

15 Oct `22Cairo, EGYPT
Topical 5-Fluorouracil Effervescent Powder in the Treatment of Vitiligo

 

Official Title: Development and Clinical Evaluation of Topical 5-Fluorouracil Effervescent Powder Formulation in the Treatment of Vitiligo

Brief Summary: A novel approach for 5-Fluo...

11 Oct `22Detroit, Michigan, USA
A Study to Assess the Changes in Pigmentation and Safety of Afamelanotide in Patients With Vitiligo on the Face

 

Official Title: An Open Label, Phase II Study to Assess the Changes in Pigmentation and Safety of Subcutaneous, Bioresorbable Afamelanotide Implants in the Treatment of Vitiligo on the Face

...
07 Sep `22Denver, Colorado, USA
Active NBUVB plus Crisaborole and and PF-07038124 topical ointment

 

Official Title: Study of Efficacy, Safety and Tolerability of Crisaborole and PF-07038124 With and Without NBUVB in Vitiligo: A Phase 2A Randomized, Double-Blind, Vehicle-Controlled Clinical Tri...

01 Aug `22Charleston, South Carolina, USA
Daily Topical Rapamycin for Vitiligo

 

Official title: Daily Topical Rapamycin Therapy for the Treatment of Vitiligo

Brief Summary: In current Dermatology practice, options for vitiligo remain limited. The purpose of thi...

02 Jun `22Multiple locations, FRANCE
Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo

 

Official Title: Efficacy and Tolerance of the Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo: a Randomized Double-blind Pro...

30 May `22Dhaka, BANGLADESH
Role of Tofacitinib in Vitiligo Patients

 

Official Title: Efficacy of Tofacitinib in Vitiligo: a Randomized Controlled Trial in a Selected Tertiary Level Hospital in Dhaka

Brief Summary: St...

05 May `22Multiple locations: USA, CANADA
A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream With Phototherapy in Participants With Vitiligo

 

Official Title: A Safety and Efficacy Study of Ruxolitinib Cream Combined With Narrow-Band Ultraviolet B Phototherapy in Participants With Vitiligo

Experimental:

- Group A: Ruxol...

15 Mar `22South Valley University, EGYPT
Comparative Study Between Topical 5-fluorouracil and Latanoprost in Vitiligo

 

Official Title: Efficacy of Topical 5-fluorouracil Versus Topical Latanoprost With Microneedling in Localized Stable Vitiligo: A Randomised Clinical Trial

Brief Summary: This study ...

10 Mar `22Banhā, EGYPT
Ocular Changes in Vitiligo Patients on Therapy

 

Official Title: Chorioretinal Changes in Vitiligo Patients on Therapy


Brief Summary: Vitiligo patients on systemic and local therapy may have some ocular adverse effects assoc...

18 Feb `22Worcester, MA, USA
Vitiligo Clinical Research Study at UMass

Official title: Evaluating an investigational medication to see if it may safely and effectively treat adults with non-segmental vitiligo.

Ages eligible: 18-65 years of age

Stipend: Receiv...

10 Feb `22Tel-Aviv, ISRAEL
Enhanced Transcutaneous Delivery of Betamethasone for the Treatment of Vitiligo

 

Official Title: Enhanced Transcutaneous Delivery of Betamethasone for the Treatment of Vitiligo

In brief: Vitiligo is a psychologically devastating...

01 May `21Bordeaux, FRANCE
Evaluation of Effect and Tolerance of the Association of Baricitinib and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo (BARVIT)

 

In brief: This is a multicenter, randomized, non-comparative, phase II proof-of-concept trial involved patients with progressive vitiligo and uses one of the most common regimen...

01 Sep `17Baltimore, USA
Early Molecular Changes After NB-UVB

Official Title: Early Molecular Changes in Vitiligo After Narrowband Ultraviolet Therapy

In Brief: This is an investigator-initiated, single-blinded, ascending do...

Past Trials

  • 22 Sep `21Dallas, TX, USAA Study to Evaluate the Efficacy of Microneedling as a Stand-alone Treatment for Vitiligo
      In brief: Microneedling is a minimally invasive technique developed for skin rejuvenation. In the treatment for vitiligo, the procedure causes micro-inflammations on the epidermis and enhances melanocytes and keratinocytes migration. This proce...
  • 25 Jan `21Alexandria, EGYPTComparison Between Systemic Steroids, Topical Steroids, or Calcineurin Inhibitors With Mini Punch Grafting in Treatment of Stable Non-segmental Vitiligo
      In brief: The study to compare the outcomes of mini punch grafting in patients with resistant stable non-segmental vitiligo already on narrowband ultraviolet B and receiving either no additional medication , systemic mini pulse (high and low do...
  • 01 Jan `21Brandon, FL USAEvaluate the efficacy and safety of investigational medication
      Official title: A Phase III, randomized, double blind, placebo controlled study to evaluate the efficacy and safety of AS012 in subjects with nonsegmental vitiligo Ages eligible: 18 + years of age Stipend: Receive compensation for your time a...
  • 25 Sep `20Worcester, University of Massachusetts, MA, USAStudy to Evaluate RECELL and MKTP for Repigmentation of Stable Vitiligo Lesions
      Official Title: Feasibility Study to Evaluate RECELL and Melanocyte Keratinocyte Transplantation Procedure for Repigmentation of Stable Vitiligo Lesions In Brief: Prospective randomized within-subject controlled feasibility study to evaluate t...
  • 10 Sep `20USA, multiple locationsStudy to Investigate the Safety and Effectiveness of RECELL for Repigmentation of Stable Vitiligo Lesions
      Official Title: Multi-Arm Clinical Study to Investigate the Safety and Effectiveness of RECELL for Repigmentation of Stable Vitiligo Lesions In Brief: This is a prospective study to evaluate the application of Spray-On Skin™ Cells, prepared us...
  • 20 Nov `19Tunis, TUNISIAEvaluation of the Efficacy of a Dermocosmetic Product
    Official Title: Evaluation of the Efficacy and the Cutaneous Acceptability of a Dermocosmetic Product in the Repigmentation of Vitiligo In Brief: Comparative study, Lithium liposome  versus placebo in intra-individual study. Ages Eligible: 18 Ye...
  • 18 Nov `19New York, USAStress Response Pathways in Vitiligo
      Official Title: Stress Response Pathways in Vitiligo: A Prospective, Investigator Initiated, Interventional Study With Two Arms In brief: Current treatments vary in effectiveness and may not always be long lasting cases. The purpose of this st...
  • 01 Nov `19Multicenter, USADonate blood for vitiligo research study
    Vitiligo Research Foundation has teamed up with Sanguine, a provider of at-home clinical research services, to give you the opportunity to contribute to the development of new Vitiligo treatments from home. Participation requires a simple blood d...
  • 03 Oct `19Multicenter, USAIncyte: Ruxolitinib cream (TRuE-V2)
    Official Title: Topical Ruxolitinib Evaluation in Vitiligo Study 2 (TRuE-V2) In Brief: The purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream in adolescent and adult participants with non-segmental vitiligo for whom...
  • 25 Sep `19Worcester, USADermavant Sciences: Cerdulatinib Gel
    Official Title: A Phase 2a, Randomized, Double-Blind, Vehicle-Controlled Study to Assess the Safety, Tolerability, and Systemic Exposure of Cerdulatinib Gel, 0.37% in Adults With Vitiligo.  In Brief: Cerdulatinib 0.37% gel applied topically twice...
  • 20 Sep `19Multicenter, USAIncyte: Ruxolitinib cream (TRuE-V1)
    Official Title: Topical Ruxolitinib Evaluation in Vitiligo Study 1 (TRuE-V1): A Phase 3, Double-Blind, Randomized, Vehicle-Controlled, Efficacy and Safety Study of Ruxolitinib Cream Followed by an Extension Period in Participants With Vitiligo. I...
  • 17 Jun `19Nice, FRANCEGlisodin with UVB
    Official Title: Gastroprotected Superoxide Dismutase in Combination With UVB vs Placebo and UVB for Treating Vitiligo. A Randomized Double Blind Placebo Controlled Monocentric Study In Brief: Glisodin 4 pills a day (1000mg) for 3 months then 2 pi...
  • 30 May `19Chicago, USAGut and Skin Microbiome
    Official Title: The Gut and Skin Microbiome in Vitiligo Disease Progression In Brief: Investigators plan to perform a pilot study that aims to characterize the microbiome of human vitiligo patients with both active and stable disease and compare ...
  • 26 Nov `18USA, CANADA, BELGIUM, GERMANY, JAPAN, KOREA, SPAIN, TAIWANPfizer: PF-06651600 and PF-06700841
    Official Title: A Phase 2B randomized, double-blind, placebo-controlled, multicenter, dose-ranging study to evaluate the efficacy and safety profile of PF-06651600 with a partially blinded extension period to evaluate efficacy and safety of PF-066...
  • 01 Nov `18Cairo, EGYPTSkin Color in Stabilization of Vitiligo by UVB
    Official Title: Contribution of Skin Color in Stabilization of Active Cases of Vitiligo by Narrow Band UVB In Brief: Vitiligo is a disease in which autoimmunity plays a major role. Multiple treatment options are available, of which narrow-band UV...
  • 18 Sep `18Xi'an, CHINAGut Microbiome and Metabolic Pathways
    Official Title: The Gut Microbiome and Metabolic Activity in Patients With Vitiligo In Brief: Vitiligo is a chronic depigmenting autoimmune-associated skin disease and a growing psychological health concern because of its low quality of life. Gen...
  • 30 Aug `18Yonsei, REPUBLIC OF KOREAInvestigation on the Expression of HMGB1
    Official Title: The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity In Brief: Vitiligo is an...
  • 13 Apr `18Porto Alegre, BRAZILSurgical Treatment of Vitiligo
    Official Title: Comparative Study of Surgical Treatment of Vitiligo: Microneedling Versus Microneedling With Suspension of Uncultured Epidermal Cells In Brief: A comparative study for the surgical treatment of vitiligo in which the same patient w...
  • 19 Mar `18multicenter, USAAclaris Therapeutics: Topical Solution
    Official title: An Open-Label Pilot Study of the Safety, Tolerability and Efficacy of ATI-50002 Topical Solution Administered Twice-Daily in Adult Subjects With Non-Segmental Facial Vitiligo In brief: This is a multicenter, open-label study desig...
  • 18 Mar `18USAAclaris Therapeutics: ATI-50002
    Official Title: A Study of ATI-50002 Topical Solution for the Treatment of Vitiligo In Brief: The main objective of this study is to assess the safety, tolerability and efficacy of ATI-50002 Topical Solution, 0.46% in subjects with non-segmental ...
  • 01 Jan `18Xi'an, CHINAEffects of Camouflage on the Life Quality
    Official Title: Development and Psychometric Validation of the Chinese Version of Vitiligo Life Quality Index and Effects of Camouflage on the Life Quality of Patients With Vitiligo: A Randomized Open-label Controlled Study In Brief: Vitiligo is ...
  • 11 Aug `17Bydgoszcz, POLANDSimvastatin And Atorvastatin Effect On Vitiligo
    Official Title: The Evaluation of Vitiligous Lesions Repigmentation After the Administration of Atorvastatin Calcium Salt and Simvastatin-acid Sodium Salt in Patients With Active Vitiligo (EVRAAS) In Brief: The aim of this study is to evaluate th...
  • 01 Jul `17Chandigarh, INDIAComparison of Surgical Methods
    Official Title: A Comparative Study Between Autologous Mini Punch Grafting, Suction Blister Grafting and Non-Cutured Epidermal Cell Suspension on Resistant Sites in Stable Vitiligo In Brief: Comparing the Efficacy of Three Different Surgical Meth...
  • 21 Apr `17New York, USACelgene: Apremilast with NB-UVB
    Official title: A Split Body Study of the Effects of Combined Therapy With Narrow-Band Ultraviolet B Phototherapy and Apremilast for the Treatment of Vitiligo. Phase II In brief: Procedure: Each participant will be compared with one side of th...
  • 04 Apr `17Multicenter, USAIncyte: A Study of Ruxolitinib 1,5% cream
    Official Title: A Study of INCB018424 Phosphate Cream in Subjects With Vitiligo In Brief: The purpose of this study will be to examine the efficacy, safety, and tolerability of ruxolitinib cream in subjects with vitiligo. Description: Ruxolitini...
  • 30 Jan `16Multicenter, USAIncyte: Topical Ruxolitinib for the Treatment of Vitiligo
    Official Title: Topical Ruxolitinib for the Treatment of Vitiligo In Brief: The purpose of this study is to determine if topical ruxolitinib 1.5% will provide repigmentation in vitiligo lesions. Description: The hypothesis is that JAK inhibitors...
  • 21 Jan `16Nice, FRANCEEfficacy of Micro-holes
    Official Title: Comparison of the Efficacy of Micro-holes vs. Laser-assisted Dermabrasion, for Repigmenting in Vitiligo Skin In Brief: The principal objective is to compare the efficacy of laser-assisted dermabrasion + autologous epidermal cells ...

FAQOther Questions

  • Does halo nevi affect vitiligo development?

    Halo nevi (also known as Sutton's nevi) are characterized by a mole that's surrounded by a ring of depigmented or lighter skin. While both halo nevi and vitiligo involve the des...

  • Will it spread?

    Vitiligo activity may vary considerably from person to person. The natural course of vitiligo is truly unpredictable but usually progressive. The most recent VALIANT study on v...

  • What is the best therapy for localized vitiligo?

    Localized vitiligo, where the white patches are limited to one or a few areas of the body, can be managed with a few treatment approaches. The best therapy usually depends on th...