Our work is entirely funded by private donations – we receive no money from government. Your money will help us continue funding research into vitiligo and supporting people affected by the condition.
Publication
Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility
This 2012 study, published in Archives of Dermatological Research, investigates candidate gene polymorphisms associated with non-segmental vitiligo in a Russian population sample (100 patients and 100 healthy controls). A strong, statistically significant association was identified between vitiligo and the GSTP1 gene polymorphism rs1138272. The rs1138272 polymorphism causes an amino acid substitution (Ala114Val) that downregulates the activity of glutathione-S-transferase P1, a phase II detoxification enzyme. Decreased enzyme activity impairs cellular redox control and oxidative stress response, which likely contributes to vitiligo pathogenesis. Haplotype and single-SNP analyses also suggested potential disease susceptibility links with LPP, GNB3, NAT2, NOS3, DDC, and the HLA-A region.
The findings highlight the critical role of Phase II detoxication/antioxidant defense systems in vitiligo and support a multigenic model where multiple low-risk alleles cumulatively increase overall disease susceptibility.
Minashkin MM, Salnikova LE, Lomonosov KM, Korobko IV, Tatarenko AO.
FAQOther Questions
- How long does it take to treat vitiligo?
Vitiligo, a condition characterized by the loss of skin pigment, can be unpredictable in both progression and treatment. The time it takes to treat vitiligo varies significantly...
- How smoking affects vitiligo?
Smoking is a common habit linked to numerous health risks, affecting multiple body systems and increasing various disease risks, including respiratory and cardiovascular issues....
- Who is prone to vitiligo?
Vitiligo can affect anyone, regardless of gender, age, or race. Vitiligo prevalence is between 0.76% and 1.11% of the U.S. population, including around 40% of those with the con...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
Many people deal with vitiligo while remaining in the public eye, maintaining a positive outlook, and having a successful career.
Copyright (C) Bodolóczki JúliaBy taking a little time to fill in the anonymous questionnaire, you can help researchers better understand and fight vitiligo.