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Publication
Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility
This 2012 study, published in Archives of Dermatological Research, investigates candidate gene polymorphisms associated with non-segmental vitiligo in a Russian population sample (100 patients and 100 healthy controls). A strong, statistically significant association was identified between vitiligo and the GSTP1 gene polymorphism rs1138272. The rs1138272 polymorphism causes an amino acid substitution (Ala114Val) that downregulates the activity of glutathione-S-transferase P1, a phase II detoxification enzyme. Decreased enzyme activity impairs cellular redox control and oxidative stress response, which likely contributes to vitiligo pathogenesis. Haplotype and single-SNP analyses also suggested potential disease susceptibility links with LPP, GNB3, NAT2, NOS3, DDC, and the HLA-A region.
The findings highlight the critical role of Phase II detoxication/antioxidant defense systems in vitiligo and support a multigenic model where multiple low-risk alleles cumulatively increase overall disease susceptibility.
Minashkin MM, Salnikova LE, Lomonosov KM, Korobko IV, Tatarenko AO.
FAQOther Questions
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Laser therapy is actually a type of phototherapy. Both rely on light to trigger changes in the skin, but they work differently. Phototherapy usually means a narrow-band UV (NB-U...
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While it's not always possible to quickly stop vitiligo progression, there are some treatments that can help slow or halt the spread of the condition in many cases: Corticostero...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
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