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Official Title: A Safety and Efficacy Study of Ruxolitinib Cream Combined With Narrow-Band Ultraviolet B Phototherapy in Participants With Vitiligo
Experimental:
- Group A: Ruxolitinib + Narrow-Band Ultraviolet B Phototherapy (NB-UVB)Participants will initially apply ruxolitinib 1.5%mg cream as a monotherapy. At week 12, those who have < 25% improvement in total body Vitiligo Area Scoring Index (T-VASI25) will have NB-UVB phototherapy added to their ruxolitinib 1.5% cream BID regimen. NB-UVB will be given 3 times per week starting at Week 12 through Week 48 (36 weeks). For participants who receive combination therapy, NB-UVB machines will be supplied by the sponsor for at home use during the study.
- Group B: Ruxolitinib MonotherapyParticipants will apply ruxolitinib 1.5% cream BID as monotherapy. Participants who have ≥ T-VASI25 at Week 12 will continue on ruxolitinib 1.5% cream BID alone.
Device: NB-UVB phototherapyNB-UVB (311-312 nm) phototherapy is an established treatment modality for vitiligo. Starting dose will be 200 mJ/cm2 and dose may be increased by 10% at each visit
Actual Study Start Date: May 5, 2022
Estimated Study Completion Date: January 23, 2024
Contact: Incyte Corporation Call Center (US)
1.855.463.3463
medinfo@incyte.com
Contact: Incyte Corporation Call Center (ex-US)
+800 00027423
eumedinfo@incyte.com
https://beta.clinicaltrials.gov/study/NCT05247489
FAQOther Questions
- Is vitiligo contagious?
Vitiligo is NOT contagious. It cannot be passed on or caught from touching someone with vitiligo, shaking hands, swimming in the same pool, sharing towels, sitting next to someo...
- Does vitiligo increase the risk of skin cancer?
No, it does not. Despite common misconceptions, people with vitiligo are actually at a lower risk of developing skin cancer, including both nonmelanoma skin cancer (NMSC) and ma...
- Is there a traditional medicine to treat vitiligo?
Traditional medicines may be helpful in chronic, metabolic, and stress-related conditions early in the disease manifestation, before extensive tissue and organ damage has occurr...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
Many people deal with vitiligo while remaining in the public eye, maintaining a positive outlook, and having a successful career.
Copyright (C) Bodolóczki JúliaBy taking a little time to fill in the anonymous questionnaire, you can help researchers better understand and fight vitiligo.