No study locations reported - 20 May `26Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"

Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"

Official title: Comparative Clinical and Histopathological Study of Microneedling With Topical Minoxidil 5% Versus Microneedling With Topical Minoxidil 5% Combined With Narrow-Band Ultraviolet B Phototherapy in the Treatment of Stable Vitiligo

Status: Opening soon

Description:

This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo. It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo. Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact. The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin. The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis

Phase: Phase 2.

What is being studied: combination products — microneedling with minoxidil 5% and NBUVB, Microneedling with Minoxidil5%.

Who can take part: ages 16 Years to 60 Years, 30 participants planned.

Enrollment status: Opening soon. The study started 20 May 2026 and is expected to finish 15 October 2027.

Contact: Rasha Hesham el dein mohammed, Bachelor.

Source: ClinicalTrials.gov, NCT07548918 (https://clinicaltrials.gov/study/NCT07548918).

Start date: May 20, 2026

Completion date: October 15, 2027

Organizer: Sohag University

Contact: Rasha Hesham el dein mohammed, Bachelor

Tel.: +201111199719

Email: rashahesham15@gmail.com

Link: https://clinicaltrials.gov/study/NCT07548918

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