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TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients
Official title: TRPM2 Gene Polymorphism in Relation to NLRP3 Inflammasome Expression in Vitiligo Patients
Status: Closed to new participants
Description:
This study investigates the relationship between Transient Receptor Potential Melastatin 2 (TRPM2) gene polymorphism and Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome expression in patients with vitiligo. Vitiligo is a common autoimmune depigmenting disorder characterized by melanocyte destruction associated with oxidative stress and immune dysregulation. TRPM2 is a calcium-permeable cation channel activated by oxidative stress, while NLRP3 inflammasome activation promotes inflammation through interleukin-1β (IL-1β) and interleukin-18 (IL-18) release. This study aims to evaluate TRPM2 genetic variants, NLRP3 expression levels, and their possible correlation with disease severity measured using the Vitiligo Area Scoring Index (VASI).
Who can take part: ages 18 Years, 60 participants planned.
Enrollment status: Closed to enrollment. The study started 20 October 2025 and is expected to finish 01 May 2027.
Source: ClinicalTrials.gov, NCT07232238 (https://clinicaltrials.gov/study/NCT07232238).
Start date: October 20, 2025
Completion date: May 01, 2027
Organizer: Aswan University
Link: https://clinicaltrials.gov/study/NCT07232238
The registry does not list a contact for this study. Use the link above to reach the study record on ClinicalTrials.gov.
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