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Tyrosine Vs Tacrolimus With NB-UVB in Vitiligo
Official title: Comparative Efficacy of Topical Tacrolimus Versus Tyrosine as Co-Therapy to NB-UVB in Vitiligo: A Randomized Intra-Individual Controlled Clinical Trial
Status: Closed to new participants
Description:
The goal of this clinical trial is to learn if adding topical tacrolimus or topical tyrosine to narrowband UVB phototherapy works to treat vitiligo in adults. It will also learn about the safety of both combinations. The main questions it aims to answer are: Which combination (UVB + tacrolimus or UVB + tyrosine) leads to greater skin repigmentation (color return) after 3 months of treatment? What side effects do participants experience with each combination? Researchers will compare three groups: UVB + tacrolimus, UVB + tyrosine, and UVB only to see which is more effective and safer. Participants will: Receive narrowband UVB phototherapy sessions two times per week at minimal erythema dose Apply either topical tacrolimus or topical tyrosine to their vitiligo patches twice daily Visit the clinic every one month for skin examination and photography Report any side effects or skin reactions
What is being studied: device — Narrowband UVB Phototherapy; drugs — Topical Tacrolimus 0.1% ointment, Topical Tyrosine 2% cream.
Who can take part: ages 18 Years to 65 Years, 67 participants planned.
Enrollment status: the registry has not updated this study since its planned completion date, so its current status is unclear. The study started 01 August 2025 and was due to finish 10 April 2026.
Source: ClinicalTrials.gov, NCT07532330 (https://clinicaltrials.gov/study/NCT07532330).
Start date: August 01, 2025
Completion date: April 10, 2026
Organizer: Minia University
Link: https://clinicaltrials.gov/study/NCT07532330
The registry does not list a contact for this study. Use the link above to reach the study record on ClinicalTrials.gov.
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