New
A couple of weeks ago, Incyte has announced its new FDA-approved topical cream Opzelura (ruxolitinib) for the short-term treatment of the atopic dermatitis. At the recent annual meeting of the European Academy of Dermatology and Venereology, Incyte has presented detailed results from the Phase 3 TRuE-V clinical trial program focused on vitiligo.
Findings revealed that twice-daily treatment with 1.5% ruxolitinib cream resulted in facial repigmentation after 24 weeks: 30% of patients achieved greater than 75% improvement; 50% of patients achieved greater than 50% improvement; and 15% of patients achieved more than 90% improvement. A significant proportion of patients also achieved more than 50% improvement on their body as well. For both areas of the body, no serious treatment-related adverse events were reported, according to the company.
However, this class of drugs recently received a setback with the FDA’s September 1st announcement that it will now require warnings about increased risk of serious heart-related events, blood clots, cancer, and death for skin disease treating JAK inhibitors.
On the heels of promising data from clinical trials and FDA concerns regarding ruxolitinib, HCPLive spoke with Dr. Lawrence Eichenfield and Dr. David Rosmarin. “So, the study that was done in <...> monotherapy, and ruxolitinib alone was able to have a significant impact,” Rosmarin said. “However, perhaps in combination (with phototherapy), it can help patients even more so and do it more rapidly.”
FAQOther Questions
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If you have vitiligo, you might wonder about the chances of your children developing the condition. While there is a genetic component, vitiligo is not a straightforward heredit...
- Is it Bitiligo? Vitaligo? Veteligo?
There are so many different ways that people try and spell or even pronounce Vitiligo. Here are some common mis-spellings: bitiligo, vitigo, vitaligo, vitilago, vitiglio, vita...
- What's better: laser or phototherapy?
Both laser treatment and phototherapy are effective options for treating vitiligo, but they each have their own advantages and considerations: Laser Treatment Advantages:- Hig...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
Many people deal with vitiligo while remaining in the public eye, maintaining a positive outlook, and having a successful career.
Copyright (C) Bodolóczki JúliaBy taking a little time to fill in the anonymous questionnaire, you can help researchers better understand and fight vitiligo.