Podcasts - 15 Sep `25Biologics, Creams, and the Safety Factor in Vitiligo (Ep. 44)

Podcast

Vitiligo care is finally breaking free from the old routine of steroids and phototherapy. Biologics like JAK inhibitors are driving impressive repigmentation in trials, while ruxolitinib cream made history as the first FDA-approved topical.

But the real headline is safety. A decade of FDA reports on tacrolimus, pimecrolimus, and ruxolitinib shows mostly mild, local side effects — yet a few rare surprises too, from tacrolimus-linked heart rhythm changes to ruxolitinib cases of anemia and pericarditis. None fatal, none disabling — but proof that “topical” doesn’t mean “risk-free,” especially with long-term or large-area use.

We also explore the essentials: how dosing shapes results, how quickly patients improve, and where these treatments are headed.

By 2026–2028, expect longer-lasting repigmentation, fewer steroids, and more personalized options. Until then: cautious optimism, careful reading of labels, and a close eye on what’s next.

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FAQOther Questions

  • What are risks of oral and topical corticosteroids?

    Corticosteroid drugs (like hydrocortisone, and others) are often used for treating vitiligo. By mimicing the effects of hormones your body produces naturally in your adrenal gla...

  • What is the best therapy for localized vitiligo?

    Localized vitiligo, where the white patches are limited to one or a few areas of the body, can be managed with a few treatment approaches. The best therapy usually depends on th...

  • Is vitiligo contagious?

    Vitiligo is not contagious. This means it cannot be spread from person to person through physical contact, sharing personal items, or any other means of transmission. Vitiligo ...