Publication - 2016Glabrous lesional stem cells differentiated into functional melanocytes: new hope for regimentation

Publication

This study is designed to check the glabrous lesional skin for the presence of stem cells as source of melanocytes for repigmentation. Our results demonstrate that NGFRp75-positive stem cells are present in the glabrous lesional skin of vitiligo patients and can be differentiated into melanocytes. These dermal stem cells showed self-renewal capacity and were capable of differentiating into melanocytes which are required for the repigmentation. Presence of stem cells in the glabrous lesional skin which are capable of self-renewal and differentiating into melanocytes gives new hope for vitiligo patients having lesion on the glabrous skin. However, still repigmentation of glabrous lesional skin is very difficult and rare with current available treatments. This clearly means that treatments available till date are not effective enough to activate these dermal stem cells differentiation and their migration to the lesional epidermis. Stimulating these stem cells to differentiate into melanocytes and migrate to lesional epidermis can be ideal for repigmentation of the glabrous lesions.

R. Kumar, D. Parsad, S. Rani, S. Bhardwaj, N. Srivastav



FAQOther Questions

  • How smoking affects vitiligo?

    Smoking is a common habit linked to numerous health risks, affecting multiple body systems and increasing various disease risks, including respiratory and cardiovascular issues....

  • PTSD in Vitiligo?

    Living with vitiligo often involves more than managing visible skin changes. Many individuals face discrimination, social stigma, and feelings of isolation, leading to emotional...

  • Can Ginkgo Biloba help with vitiligo?

    Ginkgo Biloba offers a promising, simple, and relatively affordable option for managing vitiligo. Known for its anti-inflammatory, immunomodulatory, and antioxidant properties, ...