Senescence grey hair equally affects women and man. To-date, the only treatment available for grey hair is application of temporary hair dye which needs to be applied frequently and often adversely effect the hair, hair follicle, and scalp. Numerous mechanisms, acting at different levels and follicular locations, contribute to hair greying, ranging from melanocyte stem cells defects to follicular melanocyte death. At the hair follicle stem cells niche, oxidative stress, accelerated by B-cell lymphoma 2 gene depletion, leads to selective apoptosis and diminution of melanocyte stem cells, reducing the repopulation of newly formed anagen follicles. A marked reduction in catalase expression and activity results in accumulation of hydrogen peroxide, contributing to bulbar melanocyte malfunction and death. Successful repigmentation of the hair is often observed in vitiligo patients. In vitiligo patients, hair follicular transplantation is one of the various surgical modalities that are performed to re-pigment skin lesions affected by vitiligo. The procedure is based on the concept of existence of undifferentiated stem cells in the hair follicle, which forms a good source of melanocytes for repigmentation.