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FAQ
The tropical fern Polypodium leucotomos (also known as Polypodium aureum) and its relative Polypodium decumanumhave shown potential benefits for managing vitiligo and other autoimmune and inflammatory conditions. Native to Honduran rainforests and other parts of Latin America, this fern has been used in traditional medicine for centuries, known as 'samambaia' in Brazil and 'calaguala' in Spanish-speaking countries.
Traditional Uses and Modern Applications
Indigenous communities have long used P. leucotomos to treat conditions like vitiligo, psoriasis, arthritis, and lupus. Mayans initiated its use as a blood-cleansing tea, a tradition still observed in Honduras today.
Modern clinical studies have confirmed its efficacy, particularly for facial vitiligo. Patients who combined 250 mg of P. leucotomos extract taken three times daily with NB-UVB phototherapy twice weekly over six months experienced significant repigmentation in the head and neck areas. Results were most pronounced in individuals with lighter skin tones (Fitzpatrick types II and III), and no notable effects were seen in other body areas.
How Does Polypodium Leucotomos Work?
The fern's mechanism of action is complex, offering multiple layers of skin protection:
- Free Radical Scavenging: Neutralizes harmful reactive oxygen species (ROS).
- Langerhans Cell Protection: Prevents immune system depletion in the skin.
- Sunburn Cell Reduction: Minimizes UV-induced damage.
- DNA Protection: Inhibits the formation of UVB-induced cyclobutane pyrimidine dimers, which are linked to cancer.
Benefits Beyond Vitiligo
Orally administered P. leucotomos extract also acts as a photoprotective agent, providing hours of protection against sunburn (erythema) and offering antioxidant benefits at a deeper cellular level. This is a significant advantage over topically applied antioxidants, which only work on the skin's surface.
Dosage and Safety
Supplements containing P. leucotomos extract, such as Heliocare® and Calaguala, are widely available. The typical recommended dosage is 2-3 capsules twice daily, depending on the formulation.
While P. leucotomos has shown an excellent safety profile, it has not been clinically tested in children under 18, pregnant women, or breastfeeding mothers.
The Bottom Line
With its antioxidant, anti-inflammatory, and photoprotective properties, Polypodium leucotomos offers promising support for managing vitiligo, particularly when combined with NB-UVB phototherapy. However, its use should complement—not replace—conventional treatments, and patients should consult their healthcare provider before starting supplementation.
Suggested reading
- Is there a traditional medicine to treat vitiligo?
- Diet, Microbiome, and Vitiligo: Unveiling the Mystery
- Is there a special diet for vitiligo?
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