News - 10 Oct `16Breakthrough research in genetics of vitiligo

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In a study published in the Journal Nature Genetics today, Prof. Richard Spritz, MD, Director of the Human Medical Genetics and Genomics Program at the University of Colorado, and a team of international researchers, - including VRF - announced new genetic links to vitiligo. Researchers conducted genome-wide association studies on 4,680 people with vitiligo and 39,586 control cases and found the genes that provide a framework for the genetic architecture and biological mechanisms of vitiligo. They also highlight relationships with other autoimmune diseases and melanoma.

By identifying new genes and specifics of gene regulations, the investigators can highlight and further investigate potential targets for treatment. A better understanding of the causes of vitiligo could also lead to breakthroughs in other conditions, such as: thyroid disease, pernicious anemia, rheumatoid arthritis, type 1 diabetes, Addison's disease and lupus. Read 'Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants'

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