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Researchers investigated the therapeutic potential of Ruxolitinib cream in patients with vitiligo, and it looks very promising. Results of a 2-year Phase II study at 26 medical centres in 18 states were published in the Lancet just now.
Ruxolitinib is part of a class of medications called Janus Kinase (JAK) inhibitors. Janus kinases play a significant role in the development of vitiligo, and thus blocking their signaling pathways with the drug can -- hypothetically -- treat vitiligo.
Findings from this study suggest that ruxolitinib cream might be an effective treatment option for patients with vitiligo. Once- and twice-daily application at various doses led to significant repigmentation of vitiligo lesions in the face and upper body. The highest response rate was seen with a higher dose, between 24 and 52 weeks of treatment. Some patients got 90% of the color back on the face, yet the majority reported over 50% improvement. The most common treatment-related adverse event was application site pruritus. Approximately 10% of the patients treated with the ruxolitinib cream experienced acne.
Full approval of the drug is still a ways off, but the outlook is promising. The last Phase 3 clinical trilas for Ruxolitinib cream for vitiligo is scheduled to start at the end of this year.
Update May 17, 2021: Positive Outlook For Vitiligo With Topical Ruxolitinib
FAQOther Questions
- Will it spread?
Vitiligo activity may vary considerably from person to person. The natural course of vitiligo is truly unpredictable but usually progressive. The most recent VALIANT study on v...
- Is it possible to stop the progression of vitiligo?
It is true that vitiligo progression could be stopped in 4 out of 5 cases by the use of potent systemic corticosteroids - that is, oral medications. However, systemic corticost...
- I have vitiligo: will my children have vitiligo, too?
Children born to parents who both have the disorder are more likely to develop vitiligo. However, most children will not get vitiligo even if one parent has it. In children with...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
Many people deal with vitiligo while remaining in the public eye, maintaining a positive outlook, and having a successful career.
Copyright (C) Bodolóczki JúliaBy taking a little time to fill in the anonymous questionnaire, you can help researchers better understand and fight vitiligo.