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VYNE Therapeutics Inc. recently announced positive results from the Phase 1a portion of its Phase 1a/b clinical trial evaluating its novel BET inhibitor, VYN201, for vitiligo.
This drug candidate is a locally administered, small molecule, pan-bromodomain and extra-terminal domain (BET) inhibitor. VYN201 was found to upregulate the WNT signaling pathway which is an important mediator of both melanogenesis and melanocyte differentiation and is known to be dysregulated in patients with vitiligo. Library of BET inhibitors is licensed from Tay Therapeutics Ltd, and protected by a GB patent titled 'Compounds Comprising N-Methyl-2-Pyridone, And Pharmaceutically Acceptable Salts.'
30 healthy volunteers were given single and multiple ascending doses of VYN201 ointment in five dose cohorts over two weeks, with a one-week safety follow-up visit. The doses included 0.025%, 0.1%, 0.5%, 1.0% and 2.0%, and it was generally well-tolerated with no clinically relevant adverse events from all dose cohorts.
In addition to the safety assessment, exploratory efficacy of VYN201 in non-segmental vitiligo patients will be evaluated, including pharmacodynamic biomarkers and photography.
These positive results have also caused VYNE Therapeutics shares to increase 8%.
📌 Vitiligo Drug Pipeline Analysis and Market Insights
FAQOther Questions
- Is there a traditional medicine to treat vitiligo?
Traditional medicines may be helpful in chronic, metabolic, and stress-related conditions early in the disease manifestation, before extensive tissue and organ damage has occurr...
- Is it possible to stop the progression of vitiligo?
It is true that vitiligo progression could be stopped in 4 out of 5 cases by the use of potent systemic corticosteroids - that is, oral medications. However, systemic corticost...
- What tests should be done?
A well-trained dermatologist should be able to diagnose vitiligo and distinguish it from contact leukoderma or more than twenty other conditions with similar skin appearance bas...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
Many people deal with vitiligo while remaining in the public eye, maintaining a positive outlook, and having a successful career.
Copyright (C) Bodolóczki JúliaBy taking a little time to fill in the anonymous questionnaire, you can help researchers better understand and fight vitiligo.