News - 16 Feb `23Positive Data From VYNE Therapeutics


VYNE Therapeutics Inc. recently announced positive results from the Phase 1a portion of its Phase 1a/b clinical trial evaluating its novel BET inhibitor, VYN201, for vitiligo.

This drug candidate is a locally administered, small molecule, pan-bromodomain and extra-terminal domain (BET) inhibitor. VYN201 was found to upregulate the WNT signaling pathway which is an important mediator of both melanogenesis and melanocyte differentiation and is known to be dysregulated in patients with vitiligo. Library of BET inhibitors is licensed from Tay Therapeutics Ltd,  and protected by a GB patent titled 'Compounds Comprising N-Methyl-2-Pyridone, And Pharmaceutically Acceptable Salts.'

30 healthy volunteers were given single and multiple ascending doses of VYN201 ointment in five dose cohorts over two weeks, with a one-week safety follow-up visit. The doses included 0.025%, 0.1%, 0.5%, 1.0% and 2.0%, and it was generally well-tolerated with no clinically relevant adverse events from all dose cohorts.

In addition to the safety assessment, exploratory efficacy of VYN201 in non-segmental vitiligo patients will be evaluated, including pharmacodynamic biomarkers and photography.

These positive results have also caused VYNE Therapeutics shares to increase 8%.

📌 Vitiligo Drug Pipeline Analysis and Market Insights


      FAQOther Questions

      • Is vitiligo contagious?

        Vitiligo is NOT contagious. It cannot be passed on or caught from touching someone with vitiligo, shaking hands, swimming in the same pool, sharing towels, sitting next to someo...

      • What tests should be done?

        A well-trained dermatologist should be able to diagnose vitiligo and distinguish it from contact leukoderma or more than twenty other conditions with similar skin appearance bas...

      • Shall I take vitamin D for my vitiligo?

        In Brief Vitamin D plays a central role in the prevention of different inflammatory and chronic diseases. Consuming 1,000–4,000 IU (25–100 mcg) of vitamin D3 daily should be id...